Cardiac Copper Deficiency Activates a Systemic Signaling Mechanism that Communicates with the Copper Acquisition and Storage Organs

Copper deficiency.

Copper deficiency and copper toxicity in the rat.

OWEN, CHARLES A., JR., and JANE B. HAZELRIG. Copper deJi&nc~ and copper toxicify in the rat. Am. J, Physiol. 215(Z) : 334-338. I968.-Changes in metabolism of an intravexmusly injected tracer dose of 64Cu were measured in Sprague-Dawley rats subjected to copper loading, by addition of cupric acetate to the drinking water, or made copper deficient, by use of a milk-powder diet and copper-free wat...

Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution

Copper-ionophores that elevate intracellular bioavailable copper display significant therapeutic utility against prostate cancer cells in vitro and in TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) mice. However, the pharmacological basis for their anticancer activity remains unclear, despite impending clinical trails. Herein we show that intracellular copper levels in prostate cancer, eva...

Select Cardiac Copper Chaperone Proteins Are up - Regulated by Dietary Copper Deficiency

Copper deficiency has been linked with many health problems, among them cardiac hypertrophy. Because of its potential for causing oxidative damage, copper within the cell must be bound to chaperone proteins. In this thesis, we examined the role of dietary copper deficiency in the regulation of select copper chaperone proteins in cardiac tissue of rats. Sixteen weanling male Long-Evans rats were...

Copper deficiency myelopathy.

BACKGROUND In humans, Menkes disease is the well-recognized neurological disorder due to inherited copper deficiency. Myelopathy due to acquired copper deficiency is not a well-recognized entity in humans, although myelopathy due to copper deficiency is well documented in some animal species. PATIENTS We describe 3 patients who developed a progressive spastic-ataxic gait with proprioceptive d...